Welcome To The Gene Expression Laboratory

Our lab studies the regulation of RNA polymerase II (Pol II)-dependent transcription in the fission yeast Schizosaccharomyces pombe and human cells. Specifically, we investigate how the coordinated actions of the kinases, phosphatases, and histone-modifying enzymes control transcription and various co-transcriptional processes, such as splicing, alternative polyadenylation (APA), and antisense transcription. Our research leverages integrated approaches, including biochemistry, cellular and molecular biology, classical genetics, and chemical genetics—a technique to sensitize a kinase to unnatural ATP analogs—combined with genomics and proteomics.  

Cyclin-dependent kinases (CDKs) govern the Pol II transcription cycle

Widespread regulation of Pol II transcription by kinase-phosphatase antagonisms